ParkinsonCanadaV1, Main, Exploration, bibRecord, 001552

A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease

Identifieur interne : 001552 ( Main/Exploration ); précédent : 001551; suivant : 001553

A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease

Auteurs : I. H. Richard [États-Unis] ; M. P. Mcdermott [États-Unis] ; R. Kurlan [États-Unis] ; J. M. Lyness [États-Unis] ; P. G. Como [États-Unis] ; N. Pearson [États-Unis] ; S. A. Factor [États-Unis] ; J. Juncos [États-Unis] ; C. Serrano Ramos [États-Unis] ; M. Brodsky [États-Unis] ; C. Manning [États-Unis] ; L. Marsh [États-Unis] ; L. Shulman [États-Unis] ; H. H. Fernandez [États-Unis] ; K. J. Black [États-Unis] ; M. Panisset [Canada] ; C. W. Christine [États-Unis] ; W. Jiang [États-Unis] ; C. Singer [États-Unis] ; S. Horn [États-Unis] ; R. Pfeiffer [États-Unis] ; D. Rottenberg [États-Unis] ; J. Slevin [États-Unis] ; L. Elmer [États-Unis] ; D. Press [États-Unis] ; H. C. Hyson [Canada] ; W. Mcdonald [États-Unis]

Source :

Neurology [ 0028-3878 ] ; 2012.

RBID : Pascal:12-0399393

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Placebo.

English descriptors

KwdEn :
- Nervous system diseases, Parkinson disease, Placebo.

Abstract

Objective: To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI) in the treatment of depression in Parkinson disease (PD). Methods: A total of 115 subjects with PD were enrolled at 20 sites. Subjects were randomized to receive an SSRI (paroxetine; n = 42), an SNRI (venlafaxine extended release [XR]; n ₌ 34), or placebo (n = 39). Subjects met DSM-IV criteria for a depressive disorder, or operationally defined subsyndromal depression, and scored >12 on the first 17 items of the Hamilton Rating Scale for Depression (HAM-D). Subjects were followed for 12 weeks (6-week dosage adjustment, 6-week maintenance). Maximum daily dosages were 40 mg for paroxetine and 225 mg for venlafaxine XR. The primary outcome measure was change in the HAM-D score from baseline to week 12. Results: Treatment effects (relative to placebo), expressed as mean 12-week reductions in HAM-D score, were 6.2 points (97.5% confidence interval [CI] 2.2 to 10.3, p ₌ 0.0007) in the paroxetine group and 4.2 points (97.5% CI 0.1 to 8.4, p = 0.02) in the venlafaxine XR group. No treatment effects were seen on motor function. Conclusions: Both paroxetine and venlafaxine XR significantly improved depression in subjects with PD. Both medications were generally safe and well tolerated and did not worsen motor function. Classification of Evidence: This study provides Class I evidence that paroxetine and venlafaxine XR are effective in treating depression in patients with PD.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324323

Affiliations:

Le document en format XML

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<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Rochester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Como, P G" sort="Como, P G" uniqKey="Como P" first="P. G." last="Como">P. G. Como</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Rochester</s1>
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<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Rochester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pearson, N" sort="Pearson, N" uniqKey="Pearson N" first="N." last="Pearson">N. Pearson</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>University of Rochester</s1>
<s2>Rochester, NY</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
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<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Rochester</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S. A." last="Factor">S. A. Factor</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Emory University</s1>
<s2>Atlanta, GA</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>27 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Emory University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J." last="Juncos">J. Juncos</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Emory University</s1>
<s2>Atlanta, GA</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Emory University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C." last="Serrano Ramos">C. Serrano Ramos</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>University of Puerto Rico</s1>
<s2>San Juan</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Puerto Rico</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brodsky, M" sort="Brodsky, M" uniqKey="Brodsky M" first="M." last="Brodsky">M. Brodsky</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Oregon Health Sciences University</s1>
<s2>Portland</s2>
<s3>USA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Portland</settlement>
<region type="state">Oregon</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Manning, C" sort="Manning, C" uniqKey="Manning C" first="C." last="Manning">C. Manning</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>University of Virginia</s1>
<s2>Charlottesville</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Virginia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Johns Hopkins University</s1>
<s2>Baltimore, MD</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Johns Hopkins University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L." last="Shulman">L. Shulman</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>University of Maryland</s1>
<s2>College Park</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">College Park (Maryland)</settlement>
<region type="state">Maryland</region>
</placeName>
<orgName type="university">Université du Maryland</orgName>
</affiliation>
</author>
<author><name sortKey="Fernandez, H H" sort="Fernandez, H H" uniqKey="Fernandez H" first="H. H." last="Fernandez">H. H. Fernandez</name>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>University of Florida</s1>
<s2>Gainesville</s2>
<s3>USA</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Florida</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Black, K J" sort="Black, K J" uniqKey="Black K" first="K. J." last="Black">K. J. Black</name>
<affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Washington University</s1>
<s2>St. Louis, MO</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Washington University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M." last="Panisset">M. Panisset</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Hotel-Dieu Hospital-CHUM, Notre Dame</s1>
<s2>Montreal</s2>
<s3>CAN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C. W." last="Christine">C. W. Christine</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>University of California San Francisco</s1>
<s2>San Francisco</s2>
<s3>USA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">San Francisco</settlement>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiang, W" sort="Jiang, W" uniqKey="Jiang W" first="W." last="Jiang">W. Jiang</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Duke University</s1>
<s2>Durham, NC</s2>
<s3>USA</s3>
<sZ>18 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Duke University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>University of Miami</s1>
<s2>Miami, FL</s2>
<s3>USA</s3>
<sZ>19 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Miami</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Horn, S" sort="Horn, S" uniqKey="Horn S" first="S." last="Horn">S. Horn</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>University of Pennsylvania</s1>
<s2>Philadelphia</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><settlement type="city">Philadelphie</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R." last="Pfeiffer">R. Pfeiffer</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>University of Tennessee</s1>
<s2>Knoxville</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Tennessee</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rottenberg, D" sort="Rottenberg, D" uniqKey="Rottenberg D" first="D." last="Rottenberg">D. Rottenberg</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>University of Minnesota</s1>
<s2>Minneapolis</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Minnesota</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J." last="Slevin">J. Slevin</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University of Kentucky</s1>
<s2>Lexington</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>University of Kentucky</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elmer, L" sort="Elmer, L" uniqKey="Elmer L" first="L." last="Elmer">L. Elmer</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Medical University of Ohio</s1>
<s2>Toledo</s2>
<s3>USA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Medical University of Ohio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Press, D" sort="Press, D" uniqKey="Press D" first="D." last="Press">D. Press</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Beth Israel Deaconess</s1>
<s2>Boston, MA</s2>
<s3>USA</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Beth Israel Deaconess</wicri:noRegion>
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<author><name sortKey="Hyson, H C" sort="Hyson, H C" uniqKey="Hyson H" first="H. C." last="Hyson">H. C. Hyson</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>London Health Sciences Centre</s1>
<s2>London</s2>
<s3>CAN</s3>
<sZ>26 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdonald, W" sort="Mcdonald, W" uniqKey="Mcdonald W" first="W." last="Mcdonald">W. Mcdonald</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Emory University</s1>
<s2>Atlanta, GA</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Emory University</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Placebo</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Placebo</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective: To evaluate the efficacy and safety of a selective serotonin reuptake inhibitor (SSRI) and a serotonin and norepinephrine reuptake inhibitor (SNRI) in the treatment of depression in Parkinson disease (PD). Methods: A total of 115 subjects with PD were enrolled at 20 sites. Subjects were randomized to receive an SSRI (paroxetine; n = 42), an SNRI (venlafaxine extended release [XR]; n <sub>=</sub>
 34), or placebo (n = 39). Subjects met DSM-IV criteria for a depressive disorder, or operationally defined subsyndromal depression, and scored >12 on the first 17 items of the Hamilton Rating Scale for Depression (HAM-D). Subjects were followed for 12 weeks (6-week dosage adjustment, 6-week maintenance). Maximum daily dosages were 40 mg for paroxetine and 225 mg for venlafaxine XR. The primary outcome measure was change in the HAM-D score from baseline to week 12. Results: Treatment effects (relative to placebo), expressed as mean 12-week reductions in HAM-D score, were 6.2 points (97.5% confidence interval [CI] 2.2 to 10.3, p <sub>=</sub>
 0.0007) in the paroxetine group and 4.2 points (97.5% CI 0.1 to 8.4, p = 0.02) in the venlafaxine XR group. No treatment effects were seen on motor function. Conclusions: Both paroxetine and venlafaxine XR significantly improved depression in subjects with PD. Both medications were generally safe and well tolerated and did not worsen motor function. Classification of Evidence: This study provides Class I evidence that paroxetine and venlafaxine XR are effective in treating depression in patients with PD.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Californie</li>
<li>Grand Londres</li>
<li>Maryland</li>
<li>Oregon</li>
<li>Pennsylvanie</li>
<li>Québec</li>
</region>
<settlement><li>College Park (Maryland)</li>
<li>Londres</li>
<li>Montréal</li>
<li>Philadelphie</li>
<li>Portland</li>
<li>San Francisco</li>
</settlement>
<orgName><li>Université du Maryland</li>
</orgName>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Richard, I H" sort="Richard, I H" uniqKey="Richard I" first="I. H." last="Richard">I. H. Richard</name>
</noRegion>
<name sortKey="Black, K J" sort="Black, K J" uniqKey="Black K" first="K. J." last="Black">K. J. Black</name>
<name sortKey="Brodsky, M" sort="Brodsky, M" uniqKey="Brodsky M" first="M." last="Brodsky">M. Brodsky</name>
<name sortKey="Christine, C W" sort="Christine, C W" uniqKey="Christine C" first="C. W." last="Christine">C. W. Christine</name>
<name sortKey="Como, P G" sort="Como, P G" uniqKey="Como P" first="P. G." last="Como">P. G. Como</name>
<name sortKey="Elmer, L" sort="Elmer, L" uniqKey="Elmer L" first="L." last="Elmer">L. Elmer</name>
<name sortKey="Factor, S A" sort="Factor, S A" uniqKey="Factor S" first="S. A." last="Factor">S. A. Factor</name>
<name sortKey="Fernandez, H H" sort="Fernandez, H H" uniqKey="Fernandez H" first="H. H." last="Fernandez">H. H. Fernandez</name>
<name sortKey="Horn, S" sort="Horn, S" uniqKey="Horn S" first="S." last="Horn">S. Horn</name>
<name sortKey="Jiang, W" sort="Jiang, W" uniqKey="Jiang W" first="W." last="Jiang">W. Jiang</name>
<name sortKey="Juncos, J" sort="Juncos, J" uniqKey="Juncos J" first="J." last="Juncos">J. Juncos</name>
<name sortKey="Kurlan, R" sort="Kurlan, R" uniqKey="Kurlan R" first="R." last="Kurlan">R. Kurlan</name>
<name sortKey="Kurlan, R" sort="Kurlan, R" uniqKey="Kurlan R" first="R." last="Kurlan">R. Kurlan</name>
<name sortKey="Lyness, J M" sort="Lyness, J M" uniqKey="Lyness J" first="J. M." last="Lyness">J. M. Lyness</name>
<name sortKey="Manning, C" sort="Manning, C" uniqKey="Manning C" first="C." last="Manning">C. Manning</name>
<name sortKey="Marsh, L" sort="Marsh, L" uniqKey="Marsh L" first="L." last="Marsh">L. Marsh</name>
<name sortKey="Mcdermott, M P" sort="Mcdermott, M P" uniqKey="Mcdermott M" first="M. P." last="Mcdermott">M. P. Mcdermott</name>
<name sortKey="Mcdonald, W" sort="Mcdonald, W" uniqKey="Mcdonald W" first="W." last="Mcdonald">W. Mcdonald</name>
<name sortKey="Pearson, N" sort="Pearson, N" uniqKey="Pearson N" first="N." last="Pearson">N. Pearson</name>
<name sortKey="Pfeiffer, R" sort="Pfeiffer, R" uniqKey="Pfeiffer R" first="R." last="Pfeiffer">R. Pfeiffer</name>
<name sortKey="Press, D" sort="Press, D" uniqKey="Press D" first="D." last="Press">D. Press</name>
<name sortKey="Rottenberg, D" sort="Rottenberg, D" uniqKey="Rottenberg D" first="D." last="Rottenberg">D. Rottenberg</name>
<name sortKey="Serrano Ramos, C" sort="Serrano Ramos, C" uniqKey="Serrano Ramos C" first="C." last="Serrano Ramos">C. Serrano Ramos</name>
<name sortKey="Shulman, L" sort="Shulman, L" uniqKey="Shulman L" first="L." last="Shulman">L. Shulman</name>
<name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name>
<name sortKey="Slevin, J" sort="Slevin, J" uniqKey="Slevin J" first="J." last="Slevin">J. Slevin</name>
</country>
<country name="Canada"><region name="Québec"><name sortKey="Panisset, M" sort="Panisset, M" uniqKey="Panisset M" first="M." last="Panisset">M. Panisset</name>
</region>
<name sortKey="Hyson, H C" sort="Hyson, H C" uniqKey="Hyson H" first="H. C." last="Hyson">H. C. Hyson</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson au Canada (serveur d'exploration)

A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease

A randomized, double-blind, placebo-controlled trial of antidepressants in Parkinson disease

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	La maladie de Parkinson au Canada (serveur d'exploration)
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